Raheem Sterling scored his first Manchester City goal as Chelsea lost further ground on their Barclays Premier League title rivals with a shock home defeat to Crystal Palace.
Sterling opened his City account following his £49million summer move from Liverpool with a close-range 47th minute strike against Watford.
Fernandinho was also on target in a routine 2-0 win as City claimed a fourth successive victory and opened up an eight-point advantage over stuttering Chelsea.
Jose Mourinho was celebrating his 100th home league game in charge of Chelsea but he was a Stamford Bridge loser for only the second time as Palace moved into second spot with a 2-1 victory.
Bakary Sako gave Palace a 65th-minute lead but Chelsea levelled when substitute Radamel Falcao scored his first goal for the Blues 11 minutes from time.
But Palace secured a famous victory two minutes later when Sako set up Joel Ward to fire home – Alan Pardew’s Eagles have now won three of their opening four games.
Liverpool suffered a desperate afternoon as they had key man Philippe Coutinho sent off and lost 3-0 to West Ham – the Londoners’ first win at Anfield since 1963.
Manuel Lanzini put the Hammers ahead inside three minutes and Mark Noble doubled the advantage after Dejan Lovren’s 29th-minute mistake.
Coutinho was then sent off for a second bookable offence and not even a red card for Noble could derail the Hammers as Diafra Sakho sewed up matters in stoppage time.
Stoke had two men sent off in a 1-0 home defeat to West Brom as referee Michael Oliver handed out first-half red cards to Ibrahim Afellay and Charlie Adam.
Affelay was banished for slapping Craig Gardner and Adam went for following through on Craig Dawson, and Salomon Rondon made nine-man Stoke pay on the stroke of half-time with his first goal since his £12million move from Zenit St Petersburg.
Aston Villa and Sunderland shared the points in a 2-2 draw after summer signing Yann M’Vila had given the Black Cats an early lead.
Scott Sinclair added to his Capital One Cup hat-trick in midweek with a double, one a penalty, to give Villa a half-time lead, but Jeremain Lens equalised for Sunderland seven minutes after the break to give Dick Advocaat’s side only their second point of the season.
Callum Wilson was on target for Bournemouth again in the 1-1 home draw with Leicester, following his hat-trick at West Ham.
Wilson’s overhead kick put Bournemouth ahead midway through the first half but the Cherries, who had £8million summer signing Tyrone Mings carried off on a stretcher after the break, were pegged back by Jamie Vardy’s penalty four minutes from time.